Page 42 - ESHRE2019
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Assessment of embryo viability in the IVF clinic
Pre-implantation genetic screening (PGS) to select normal embryos for transfer
Cleavage stage blastomere
Blastocyst Trophectoderm
Confined placental mosaicism
• Which embryos?
vs
• Fate of specific aneuploidies?
Disturbs diploid : aneuploid ratio Not enough cells to biopsy
Fate of aneuploid cells in embryos
Aneuploid cells elicit several cellular stress responses [Santaguida S. and Amon A. (2015)]
Aneuploidy
Oxidative Proteotoxicity stress
Genomic Stress kinase Instability p38 activation
Metabolic alterations
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