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Increased metabolic stress in aneuploid cells
+/-Reversine
Diploid
Total TE ICM
Standard/Low energy KSOM
Aneuploid
TE ICM
Standard KSOM
Low energy KSOM
(lower Glucose, no L-Glutamine, no essential or non-essential amino acids)
Total
Aneuploid embryos might have increased energy requirements Optimize in vitro culture conditions?
Acknowledgements Magdalena Zernicka-Goetz
Aga Jedrusik
Meng Zhu
Marta Shahbazi
Matteo Amitaba Mole Christos Kyprianou Neophytos Christodoulou Lorenzo Carlo Orietti Gianluca Amadei
Andy Cox
Juliet Tyndall Charlotte Handford Sylwia Czukiewska Berna Sozen
Ania Hupalowska Francesco Antonica
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PRECONGRESS COURSE 10 I VIENNA, AUSTRIA – 23 JUNE 2019 41
Cell number relative to control KSOM
