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100 90
Study #1 & #2 (1997 to 2015):
(57+36)/(13,809+5,512)=93/19,321 (≈5‰)
100 90
Type 3 CPM (n=28) Type 2 CPM (n=38)
Type 3 CPM (n=28) Type 2 CPM (n=38)
80 80
70 70
60 60
50 50
40 40
30 30 20 20 10 10
00
0 20 40 60 80 100 0 20 40 60 80 100
Percentage of placental cells with trisomy after long-term culture
Estimated percentage of whole placental cells with trisomy
p<10-2 p<10-3 (Pearson)
Study #2 conclusion
❑ No association between NT and CPM ❑ Low PAPP-A levels for type 3 CPM
→ ~2-3% of IUGR caused by CPM
❑ Association with preeclampsia ?
❑ Physiopathology of IUGR consecutive to CPM ?
→ 11/16=68.7% < 5th percentile – Type 3 CPM: 43/19,321= 0.22%
❑ Unexplained IUGR: CVS – ~75% with IUGR
63
66
Birth weight percentile
Birth weight percentile
