Page 168 - ESHRE2019

Uterine bioengineering: emulating native tissues
Decellularization of tissues and organs
Innovation
Foundation
9
Uterine bioengineering: emulating native tissues
Decellularization of tissues and organs
••TDheyneaxmtraicerellcuiplarromcitayt:rix (ECM): Important role in•celBlimdiriegcrtaiotnioanl i,npterroclhiafenrgaetbioetnwaenendthe cell and its
surrounding ECM. differentiation.
• Composition is unique and transient for every • “The ideal scaffold”:
•
Core concept for decellularization.
tissue.
• Perfect mechanical and structural support.
Dynamic and constant remodeling of the • Provider and reservoir of bioactive cues.
ECM (homeostasis or injury).
• Flexible physical heterogenous environment.
Innovation
Foundation
10
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