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Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double‐blind, multicenter, placebo‐controlled study
Yutaka Osuga, M.D.,a Haruka Fujimoto‐Okabe,b and Atsushi Hagino Fertil Steril 2017
Conclusion(s): These results suggest that DNG is effective and well tolerated in the treatment for painful symptoms
associated with adenomyosis not complicated by severe uterine enlargement or severe anemia.
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Medical treatment
• Fedele,L., Bianchi,S., Raffaelli,R. et al (1997) Treatment of adenomyosis-associated menorrhagia with a levonorgestrel-releasing intrauterine device. Fertil.Steril., 68, 426-429.
• N=25 women with adenomyosis-associated menorrhagia – Diagnosed by TVS
– levonorgestrel-releasingintrauterinedevice(IUD)
– Effective in reducing blood loss
– Decrease in uterine volume
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