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HPV infection and fertility
 One of the most prevalent STDs
increases risk of malignancy in the anogenital tract
 Negative impact on reproductive health and fertility (limited data) negative impact on all sperm parameters
no reported negative effect on female fertility parameters
 Adverse effect on ART outcome
Garolla et al. Medicine Fertil Steril 2016; 105(1) 65-72
 54 HPV infected couples v. 158 non‐infected couples undergoing IVF or ICSI • reduced cumulative pregnancy rates (38.4% v. 14.2%)
• increased miscarriage rates (62.5% v. 16.7%)
 2 meta‐analysis show no effect of HPV on ART outcome
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HPV and ART: Areas of ongoing Research
 role of HPV detection/genotyping in assessment of the infertile couple  role of HPV vaccination in both partners
Zacharis K et al. Medicine 2018; 54(4) (mini literature review) GarollaAet al. Sci Rep 2018; 8:912
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