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Disease modeling
• Hard to access processes
(CNS, lineage commitment, germline development, etc...)
• Cell populations that are scarce for study
• Short lived primary cultures
• Unknown genetic cause
• Stages of development not available (human between week 1 and 8)
Disease modeling
Animal models not always OK
Cystic fibrosis (no respiratory syndrome) Lesch‐Nyham syndrome (no neurological symptoms) ALS (drugs don’t affect the human phenotype)
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