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Disease modeling: challenges
• Of cell:
– iPSC‐epigeneticmemory
– Line specific characteristics
– Ability to differentiate to a lineage/cell type
• Of technology/system:
– Heterogeneityofdifferentiatedcells,challengeforhighcontentand
high throughput
– Fidelityofdisease
– Invitromicroenvironment/signatureoflab
Learning objectives
The concept of pluripotency and types of pluripotent stem cells Disease modelling
Toxicology & drug discovery
Translation to the clinic
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