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Drug discovery and stem cells
Improvements:
Human from discovery phase Identify good hits
Eliminate ineffective hits Detect toxic hits
Save time
Save money
(Grskovic et al, 2011)
Drug discovery and pluripotent stem cells
• Robust adult differentiation protocols towards heart and liver (for toxicity)
• High fidelity between known “bad hits” and in vitro behavior
• Controls
– Deductive = Ensure low genetic noise
– Inductive= More noise but closer to reality of diseased population
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