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Integrative delivery systems:
Retrovirus/lentivirus/linear Sox2 DNA/PiggyBac transposon
Oct4
Klf4
INDUCED PLURIPOTENT STEM CELLS
cMyc
cMyc Non integrative delivery systems:
Sox2 Oct4 Klf4
Somatic cell
Adenovirus/Sendai viral vectors/ episomal vectors/synthetic mRNA/proteins
Cell, 2006
The Nobel Prize in Physiology or Medicine 2012
was awarded jointly to Sir John B. Gurdon and Shinya Yamanaka "for the discovery that mature cells can be reprogrammed to become pluripotent"
Sir John B. Gurdon Shinya Yamanaka
SCNT iPS
26
PRECONGRESS COURSE 13 I VIENNA, AUSTRIA – 23 JUNE 2019 29
