Page 54 - ESHRE2019

First-line ovulation induction interventions
Clomiphene
WHO Group II anovulation
Gonadotropins
Clomiphene + Metformin
Placebo/No treatment
Laparoscopic Ovarian Drilling
Tamoxifen
Letrozole
Metformin
Results – network plot
• 57 RCTs, 8082 women
LOD
MF
CC
FSH LET
CC+MF
TAM
PB
Comparisons
Trials
CC vs Letrozole
15
CC vs CC+MF
15
CC vs MF
6
CC vsTamoxifen
4
CC vs Placebo
3
CC vs FSH
2
CC vs LOD
1
CC+MF vs MF
5
Met vs Placebo
5
Letrozole vs Tamoxifen
1
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