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Oocyte maturation optimizes the calcium signaling
GV Immature oocyte
Increase in the number of IP3R1 and clustering
Increase in IP3R1 sensitivity
Increase in the amount of calcium ions stored
Reorganization of ER, CGs, mitochondria and cytoskeleton
Protein synthesis
MII Mature oocyte
AOA to overcome fertilization failure is more likely to be efficient in case of a sperm‐borne activation deficiency
AOA
1) Sperm‐borne or “early” oocyte‐borne activation deficiency (oocytes’ Ca2+ releasing ability)
2) “Late” oocyte‐borne activation deficiency (downstream Ca2+ oscillations)
Tosti et al., 2016
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Adjuk et al., 2008
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