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Follow up of children born following AOA
AOA protocol
Included children
Outcome parameters
Conclusions
Kyono et al. (2008)
SrCl2
n=5, up to the age of 1 year
Pregnancy and neonatal data, developmental characteristics
Satisfactory development
Vanden Meerschaut et al. (2014)
Ionomycin
n=21, aged 3‐10 years old
Neonatal and neurodevelopmental outcome (speech, motor skills, cognition, behaviour)
Reassuring results
Deemeh et al. (2014)
Ionomycin
n=79, aged 1‐25 months old
Pregnancy data and health of children (major birth defects, mental and behavior status)
No significant differences compared with “conventional ICSI” children
Miller et al. (2016)
A23187
n=83, aged 0‐8 years old
Birth defects, next to pregnancy and neonatal outcome
No significant differences compared with “conventional ICSI” children
Effect of AOA on (epi)genetics
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