Page 98 - PCC11
P. 98
98
Fertilisation
Donor egg
Patient egg
Pronuclear stage
Examples of PGD cases at NFC
30% threshold for replacement
Case A Case B Case C Case D Case E Case F Case G Case H
% mutation load
x blastomeres x embryo replaced
Pronuclear Transfer (PNT)
Page 92 of 155
Transfer
Reconstituted fertilised egg
wild-type mitochondria
mitochondria with pathogenic mtDNA mutation
