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Global „omics“ approaches for biomarker discovery
GENOMICS
Human genome project GWAS studies
TRANSCRIPTOMICS
mRNA, microRNA
PROTEOMICS
Human proteome project https://hupo.org/human‐proteome‐project Human plasma, urine proteome
METABOLOMICS
Human metabolome project www.hmdb.ca
Human plasma, urine metabolome
7
Human proteome defines functional state of the organism
https://hupo.org/human‐proteome‐project
dubious/uncertain
2 186 proteins
evidence at the trancript level,
inferred from homology, predicted
17 470 proteins
evidence at the protein level
Omenn et al. 2018 8
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