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Pretreatment Evaluation
Important for clinical determination of stage & grade:
1. 2.
• •
Medical history
Physical examination
– Uterus size & mobility
– Metastatic disease (parametrium, cervix)
Endometrial sampling Pelvic & abdominal imaging
Endometrial Sampling
•
• •
Optimal method: Dilatation & Curettage, with or without Hysteroscopy
– SuperiortoPipelleintermsofaccuracyofthetumorgrade – finalspecimenpathologyupgrade(17,4%vs.8,7%)
Histological diagnosis should be reviewed by an expert pathologist, or even 2
– ER,PR&p53
Possible unsuspected advanced disease: – 621patientspresumedwithstageIdisease – 22%diseaseoutsidetheuterusatsurgery
Leitao MM, Jr, et al, Gynecol Oncol 2009; 113: 105–108
Ushijima K, et al, J Clin Oncol 2007; 25: 2798–2803
Creasman WT, et al, Cancer 1987; 60:2035
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