Page 38 - ESHRE2019

Ovarian cancer – survival
 Worldwide approximately 225,500 women are diagnosed with ovarian cancer annually
 75% diagnosed at Stage III and IV
 5 year Disease free survivors (DFS) 14 ‐ 18%
 70% will relapse and die
 Pelvic Serous Carcinomas (PSC) are originate mainly in the fimbriated end of fallopian tube Prophylactic salpingectomy could prevent development of PSC
 Randomized data do not yet support routine screening for ovarian cancer in the general population
 Routine screening is not currently recommended by any professional society
NCCN 2012
SCOUT
Secretory Cell OUTgrowth (PAX2- , Bcl2)
STIL
Serous Tubal Intraepthelial Lesion (P53 signature )
TILT
Tubal Intraepithelial Lesion in Transition ( p53 and Ki67+)
STIC
Serous Tubal Intraepithelial Carcinoma (p53+ and Ki67 +++)
Invasive high grade serous carcinoma
Folkins et al GO 2009
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Time ?