Page 42 - ESHRE2019

Ovarian Ca surgical staging and treatment during reproductive years causes general health and infertility problems
 Infertility
Early menopause
 Sexual function and psychology are affected  HR of CVD and CVA
 Osteoporosis
 Neurological impairment
Ovarian Ca and chemotherapy
Chemotherapy agents – gonadotoxic
depends on ‐ Age, ‐ mechanism of action, ‐ treatment dose and length
Alkylating agents are highest risk for gonadotoxicity
Platinum agents, taxanes, and anthracyclines have an intermediate
risk for gonadotoxicity
GnRH analogues have not been proved that reduce the risk of POF
40
37