Dear Colleagues and Friends,

Thank you for your positive comments on the last newsletter.

SIG-Andrology are currently finalising details for our Precongress Course for 2019. The topic is likely to be “Controversies in Andrology” with a debate format. We are really keen to hear your suggestions for what you would like debated so please let me know.

IntOmb  It will shortly be our November IUI Campus Workshop in Antwerp, you can hear more about this in a video from Willem here
The best way to stay updated about other activities is to keep an eye on our section of the ESHRE Website

Highlights in fertility preservation

A known late effect of chemotherapy and radiation is the damage and/or loss of the proliferating spermatogonial stem cells in the testis. Cryopreservation of spermatozoa is the first line treatment for fertility preservation in adolescent and adult males. For prepubertal boys, who do not yet produce sperm, alternative preservation methods are needed. In the past two decades, a lot of effort has been put to develop fertility preservation and restoration strategies for these young boys, such as testicular tissue cryopreservation and the banking of isolated spermatogonial stem cells. Although cryopreservation of testicular biopsies has been applied in clinic for more than 15 years, several questions remain unanswered. For example, the effects of the testicular biopsy procedure on the patient’s further pubertal development are still unknown.

A recent publication in Human Reproduction by Uijldert M et al.: Development of the testis in pre-pubertal boys with cancer after biopsy for fertility preservation (doi:10.1093/humrep/dex306) is the first one to address this question. The paper describes the one-year follow-up of boys having undergone a testicular biopsy procedure for fertility preservation purposes. Testicular volume was assessed by ultrasound at 1, 6 and 12 months after biopsy. Comparing the volume of the biopsied testis with that of the contralateral one, the authors concluded that testicular growth was not affected after biopsy, which is reassuring and very helpful in the counseling of future patients.

These and other recent findings in male fertility preservation will be presented during the upcoming ESHRE campus workshop co-organised by the SIG Andrology and the SIG Fertility Preservation:  Male fertility preservation: how close are we to clinical practice?, which will be held in Amsterdam on March 8-9, 2018.
Mark your agenda if you want to get an update on the latest technologies, on the progress made so far, or on current European initiatives. Special attention will be given to spermatogonial stem cell cryopreservation, transplantation and sperm development in vitro. Take the opportunty to meet all major players in the field of male fertility preservation and register today here.  

Paper highlights

In this month’s relevant paper highlights emerging from the ESHRE Journals there are many of interest. For these we have a particular focus on those that are Open or Free Access.  

Articles published in September/October 2017

“Update on fertility preservation from the Barcelona International Society for Fertility Preservation – ESHRE-ASRM 2015 expert meeting: indications, results and future perspectives”
Article available with Free Access (not Open Access)

“Complex CatSper-dependent and independent [Ca2+]i signalling in human spermatozoa induced by follicular fluid”
Article available under Open Access (CC BY).

“Prevalence of endocrine and genetic abnormalities in boys evaluated systematically for a disorder of sex development”
Article available with Open Access

Additional article that could be of general interest are:
“Clinical trial registration in fertility trials – a case for improvement?”
Article available with Free Access (not Open Access)

“The Vienna consensus: report of an expert meeting on the development of art laboratory performance indicators”
Article available with Open Access

Articles published in September/October 2016

“Anti-Müllerian hormone in seminal plasma and serum: association with sperm count and sperm motility”
Article available with Free Access

“Vitamin D deficiency and low ionized calcium are linked with semen quality and sex steroid levels in infertile men”
Article available with Free Access

“Self-reported onset of puberty and subsequent semen quality and reproductive hormones in healthy young men”
Article available with Free Access

“Prediction model for obtaining spermatozoa with testicular sperm extraction in men with non-obstructive azoospermia”
Available with Free Access

“Prediction model for live birth in ICSI using testicular extracted sperm”

Accompanying invited commentary for DEW147 and DEW146:
“Clinical decision-making in azoospermia men: in search of the ideal prediction model”

“Klinefelter syndrome and fertility: sperm preservation should not be offered to children with Klinefelter syndrome”
Available with Free Access
This is a review.

“Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p.N680S: a pharmacogenetic study
Available with Free Access.

“Seminal plasma transforming growth factor-b, activin A and follistatin fluctuate within men over time.
Available with Free Access.

“Specific immune cell and cytokine characteristics of human testicular germ cell neoplasia”
Available with Free Access.

“Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases”
Article available under Open Access.

“The human epididymis: its function in sperm maturation”
Available with Free Access.

“Potential toxicity of engineered nanoparticles in mammalian germ cells and developing embryos: treatment strategies and anticipated applications of nanoparticles in gene delivery”
Available with Free Access

“In vitro differentiation of rat spermatogonia into round spermatids in tissue culture”
Available under Open Access

“Couples with non-obstructive azoospermia are interested in future treatments with artificial gametes”
Article available with Free Access

“Prevalence of infertility and help seeking among 15 000 women and men”
Available with Open Access

The committee are always keen to hear more from you about what you would like to see organised, so please feel free to get in contact by e-mail.

Best wishes on behalf of the entire committee,

Coordinator SIG Andrology


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