Good practice recommendations on fertility preservation involving testicular tissue cryopreservation in children receiving gonadotoxic therapies

For young males facing gonadotoxic treatments, fertility preservation options are limited—especially for children and adolescents who are not yet able to produce sperm. In these cases, testicular tissue cryopreservation is increasingly being offered as a potential way to preserve fertility for the future.

However, there is currently no clear consensus on best clinical practices for testicular tissue cryopreservation. Questions remain around the most effective cryopreservation techniques, tissue quality control, patient assessment, and long-term follow-up.

This Good Practice Recommendations paper provides comprehensive guidance on fertility preservation for prepubertal boys and adolescent males who are unable to provide a sperm sample. It covers all aspects of care, from setting up a preservation program and determining eligibility, to counselling, performing the testicular tissue biopsies, and implementing cryopreservation techniques.

The recommendations paper has been published in Human Reproduction, read it here.

Working group