Marcia C. Inhorn and Pasquale Patrizio, Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century in Hum. Reprod. Update (July/August 2015) 21 (4): 411-426. doi: 10.1093/humupd/dmv016
In the current issue of Human Reproduction Update, Marcia Inhorn and Pasquale Patrizio take a fascinating journey through global infertility, combining anthropology and reproductive medicine. Infertility affects 186 million people worldwide and remains a major social burden for women. Inhorn and Patrizio discuss the, possibly preventable, causes of infertility, describe the global distribution of infertility clinics and explore the development of the low cost IVF movement in resource-poor countries. This timely and original review comprehensively documents the global scenario of reproductive medicine.
Victoria L. Yarbrough, Sean Winkle and Melissa M. Herbst-Kralovetz, Antimicrobial peptides in the female reproductive tract: a critical component of the mucosal immune barrier with physiological and clinical implications in Hum. Reprod. Update (May/June 2015) 21 (3): 353-377. doi: 10.1093/humupd/dmu065
The comprehensive article by Victoria Yarbrough and colleagues reviews the functional presence of antimicrobial peptides in the female reproduction tract. The “first line defense” of the female reproductive mucosal interface provides protection from pathogenic invasion from the external environment, similarly to that provided by dermal and gastrointestinal tract mucosal surfaces. Limiting microbial invasion and modulation of local immune responses may be crucial in many physiological and pathophysiological reproductive processes; including embryo implantation, infertility, and associated assisted reproductive technologies, maintenance of pregnancy and pregnancy complications, together with inflammatory diseases of the reproductive tract. This emerging field will be of great interest to the reproductive medicine arena.
ART and uterine pathology: how relevant is the maternal side for implantation? in Hum. Reprod. Update (January/February 2015) 21 (1): 13-38. doi: 10.1093/humupd/dmu047
Daniela Galliano, José Bellver, César Díaz-García, Carlos Simón and Antonio Pellicer
The article by Daniela Galliano et al. represents one of the largest reviews and is, by far, the most pertinent update on the fundamental question: how relevant is the maternal side for embryo implantation in ART? This outstanding search of the global literature assessed the current knowledge of endometrial receptivity in ART. Conclusions highlight the necessity for future studies to elucidate the real clinical impact of uterine and endometrial pathologies on ART.