Welcome to the section dedicated to the Special Interest Group Reproductive Genetics. Here you can read more about us, our activities and our recommended reading.
Reproductive Genetics deals with the relationship between the genotype and reproduction. This includes studying the transmission of the genetic material and its epigenetic modifications from one generation to the next and also the effects of abnormalities in this genetic material on reproduction.
In genetic terms, reproduction of an individual or couple is essential. However, the genetic make-up can hamper reproduction and the insight into how this is brought about has made genetic diagnosis and counseling important.
The aims of the SIG Reproductive Genetics are:
The first clinical application of PGT was reported in the early 1990s. The field has seen immense progression mainly in the techniques used for either chromosomal or molecular diagnosis. We have seen two-colour FISH evolve to five colour FISH, and now molecular karyotyping using array-CGH at the single cell level. Conventional PCR was replaced by fluorescent PCR, then multiplex PCR and whole genome amplification. Some groups are already using SNP arrays for PGT and genome sequencing is around the corner. Since the early days, the number of PGT cycles carried out and the number of clinics offering PGT has grown year by year. In 1997 it was decided to bring these activities together in the ESHRE PGT Consortium.
In the last issue of ESHRE's news magazine you can read about past and upcoming events.