Chromosomal mosaicism in human embryos: Incidence, prevalence, diagnostic possibilities and clinical management in PGT-A cycles

Precongress Course 10

 Special Interest Group Reproductive Genetics


Course type

Advanced

 

Course Co-ordinators

Georgia Kakourou (Greece), Claudia Spits (Belgium), Antonio Capalbo (Itlay), Francesco Fiorentino (Italy), Filippo Zambelli (Italy)


Course description
The course will provide a preliminary overview about the human aneuploidies , provide an update on existing data on the mosaicism features in the preimplantation, prenatal and postnatal period, detailed information about the detection possibilities and clinical management of chromosomal mosaicism in PGT-A cycles.

 

Target audience
Reproductive geneticists, embryologists, gynaecologists, researchers, ethicists and professionals working in ART and reproductive medicine

 

Educational needs and expected outcomes
The rapid developments in molecular genetics, including advanced technologies and a wealth of data that have been obtained particular in the last years demand to inform clinicians, embryologists, geneticists and all involved in ART on the relevance and clinical application of information. The course will provide an overview in a series of lectures by experts in the field and by offering a platform for discussions and interactions between participants and faculty.


Programme


Sunday 23 June 2019

Chairs
Georgia Kakourou, Greece
Dagan Wells, United Kingdom
09:00 - 09:30
Aneuploidies in human gametes and embryos
Eva Hoffmann, Denmark
09:30 - 09:45
Discussion
09:45 - 10:15
Risk factors and molecular mechanisms contributing to mosaicism in embryos
Joris Vermeesch, Belgium
10:15 - 10:30
Discussion
10:30 - 11:00
Coffee break
Claudia Spits, Belgium
Joris Vermeesch, Belgium
11:00 - 11:30
The fate of aneuploid cells in mosaic embryos
Shruti Singla, United Kingdom
11:30 - 11:45
Discussion
11:45 - 12:15
Prevalence and typology of mosaicism in POCs and pregnancies
Jerome Toutain, France
12:15 - 12:30
Discussion
12:30 - 13:30
Lunch break
Francesco Fiorentino, Italy
Stéphane Viville, France
13:30 - 14:00
Methodologies to study mosaicism in embryos
Nathan Treff, U.S.A.
14:00 - 14:15
Discussion
14:15 - 14:45
Prevalence of chromosomal mosaicism in IVF derived embryos
Dagan Wells, United Kingdom
14:45 - 15:00
Discussion
15:00 - 15:30
Coffee break
Antonio Capalbo, Italy
Filippo Zambelli, Spain
15:30 - 16:00
Impact of chromosomal mosaicism in IVF outcomes
Francesca Spinella, Italy
16:00 - 16:15
Discussion
16:15 - 16:45
Chromosomal mosaicism in non-invasive PGT-A
Carmen Rubio LLuesa, Spain
16:45 - 17:00
Discussion