Precongress Course 14
Johnny Awwad (Lebanon) and Mohammad Aboulghar (Egypt)
The oocyte is the key player in the sperm-egg interaction and the major determinant of embryo developmental potential. In addition to transmitting the maternal chromosomal complement, it also contributes the mitochondrial genome to the developing embryo. Surprisingly little research have focused on studying the oocyte contribution to a successful implantation. Determining oocyte quality remains restricted to a morphological analysis, a well-proven inaccurate science.
Alternative innovative strategies, the outcome of extensive research, could prove useful in enhancing the ability of the treating team to select the most competent oocytes for fertilization and subsequent embryo transfer. In addition to advancing our ability to alter reproductive pathways, such technologies have also greatly expanded our understanding of the biology of reproduction.
Oocyte competence could hence be better identified on the basis of minimally invasive enhanced diagnostic modalities, such as distribution pattern and function of mitochondria, polar body genomic analysis, cumulus cell molecular signature and many others. Some of these developments have also led to focused interventions designed to improve oocyte reproductive performance, namely mitochondrial enhancement and androgen priming.
This pre-congress course discusses biologic pathways which influence oocyte competence and evaluates diagnostic and therapeutic interventions designed to promote oocytes with the highest reproductive potential.
Educational needs and expected outcomes