Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence
in Hum. Reprod. Update (November/December 2014) 20 (6): 808-821. doi: 10.1093/humupd/dmu027
Jemma Evans et al.
In the latest issue of Human Reproduction Update, Jemma Evans and colleagues discuss the clinical validity of frozen embryo transfer (FET) as an alternative to fresh embryo transfer. Evans et al. summarise existing literature, indicating that FET is associated with a reduction in the incidence of ovarian hyperstimulation, a better pregnancy rate and improved neonatal outcome. The data shown derive from an evidence-based approach and may influence the future clinical approach to IVF.
Clinical outcomes following selection of human preimplantation embryos with time-lapse monitoring: a systematic review in Hum. Reprod. Update (September/October 2014) 20 (5): 617-631. doi: 10.1093/humupd/dmu023
Daniel J. Kaser and Catherine Racowsky
Time Lapse Monitoring (TLM) is a novel technique allowing semi-quantitative evaluation of embryo morphology and early developmental processes. In clinical practice, correlation between several morphokinetic parameters and the prediction of implantation assists embryologists in the identification of top quality embryos. The rationale of TLM is incredibly fascinating. Although currently used in some clinical laboratories, the technique remains in the early stages of development and, as discussed in the review by Racowsky and Kaser, more data are necessary to confirm its clinically reliable use. Racowsky and Kaser highlight the need for additional prospective studies before TLM is adopted as a routine procedure in assisted reproduction.
The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis in Hum. Reprod. Update (July/August 2014) Hum Reprod Update 2014;20:467-484
S.J. Han et al.
The article by Han and O'Malley in the July/August issue of the journal is the most complete review of genetic alteration, epigenetic variations and post-translational modification of nuclear receptors in endometriosis. Elucidation of these changes has identified possible new targets for the treatment of this oestrogen-dependent disease.
Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and future recommendations in Hum. Reprod. Update (May/June 2014) 20 (3): 309-333. doi: 10.1093/humupd/dmt058
James H. Segars et al.
In the latest issue of Human Reproduction Update the review by James Segars et al. discusses the newest investigations on uterine fibroids. The most common benign tumours in women, fibroids have a huge impact on reproductive function. This update reviews the most recent basic, translational and applied advances, associating them with an update on clinical management of the uterine fibroids. New medical and non-invasive, surgical treatment regimens are also discussed in great detail.