Male Reproductive Health Initiative

Mission

The Male Reproductive Health Initiative (MRHI) is a global collaboration dedicated to advancing the science and practice of male reproductive medicine. The MRHI accomplishes its mission by promoting and contributing to high quality research in both basic and clinical science, forging collaborative relationships with professional societies to contribute to a mission of education, and through advocacy of MRHI to all stakeholders including patient support groups, funding agencies, non-for-profit organizations, industry, and the public.

Strategic Goals

  1. What are current key research questions?
    • ‘Cause and effect’ dynamics between poor men’s health, male reproductive health and early death.
    • Epigenetics and transgenerational effects.

  2. What strategies should be adopted to answer the key research questions?
    • How do we address the above questions in a realistic and real-world manner?
    • What models are helpful?
    • What existing data/databases can answer these questions (preclinical, genetic, national repositories, etc.).

  3. Are there effective treatments for boosting and suppressing male fertility.
    • Current methods for diagnosing cause of male infertility are inadequate and effective treatments are lacking. To alleviate the burden women bear in consequence, research funding must be invigorated with the overarching mission to better identify and characterize essential components of the fertile male toolkit.
    • There is an urgent need (and market demand) for additional male contraceptive options but how is this to be realised?

  4. Engagement of males, their partners and the broader community, including policy makers, in MRH.
    • A fundamental objective is to assess and improve education, social awareness and involvement of men in reproductive health throughout their lifespan.
    • This will involve discussion with, for example, policy makers, industry, and funders as well as between researchers.

Contact : Christopher LR Barratt - C.barratt@dundee.ac.uk

 

Core Working Group Members

   

Richard A Anderson MD PhD FRCOG FRCP(Ed)

Affiliation
University of Edinburgh:
• Elsie Inglis Professor of Clinical Reproductive Science
• Head of Section, Obstetrics and Gynaecology
• Deputy Director, MRC Centre for Reproductive Health

Clinical and research activity
Clinical work is in male and female reproductive endocrinology and infertility. I am an investigator in a NICHD trial of a testosterone/nestorone gel for contraception. Recent clinical studies focus on the roles of the novel neuropeptides kisspeptin and neurokinin B in male/female reproductive function. I am a member of the HFEA Scientific and Clinical Advances Advisory Committee, the ESHRE Executive Committee, and am past Coordinator of the ESHRE Special Interest Group in Fertility Preservation.

 

   

Christopher LR Barratt, PhD, DSc

Affiliation
University of Dundee
• Head of Division Post Graduate Medicine Ninewells Hospital
• Head of Reproductive Medicine

Clinical and research activity
Current member of WHO Semen Analysis Manual (6th edition) Editorial Board. Past member of WHO Male Fertility Expert Working Group (2012-2017) and Human Fertilisation and Embryology Authority. Current research involves examination of sperm function and interruption of key pathways for the development of new male contraceptives.

 

   

Christopher De Jonge, PhD, HCLD(ABB)
orcid: 0000-0023-4083-5833

Affiliation
University of Minnesota
• Director, Andrology Program, University of Minnesota Medical Center
• Adjunct Professor, Department of Urology

Clinical and research activity
Current member of Guideline Development Group, WHO Guidelines on Fertility care, Infertility and Subfertility; Practice Guidelines Committee - Male Infertility Panel - American Urological Association. Past member of Evidence Synthesis Group on Male Infertility WHO Infertility Global Guidelines and Research. Board-certified high-complexity clinical laboratory director.

 

 

 

 

 

Michael L. Eisenberg, MD

Affiliation
Stanford University School of Medicine
• Associate Professor of Urology and Obstetrics & Gynecology
• Director of Men’s Health and Male Reproductive Medicine and Surgery.

Clinical and research activity
Dr. Eisenberg is associate editor of Fertility and Sterility and Andrology and an ad hoc referee for numerous leading medical journals. He has authored numerous peer-reviewed articles. His laboratory seeks to understand the association between a father’s reproductive health, overall health, and offspring health.

 Garrido  

Nicolás Garrido Puchalt, PhD

Affiliation
• Director, IVI Foundation, Instituto de Investigacion Sanitaria La Fe

Clinical and research activity
Nico obtained his Doctorate from the University of Valencia in 2001, and received the Extraordinary Prize in 2002. He was Director of the Andrology Laboratory and Sperm Bank at the IVI University Institute in Valencia from 2000 until 2016 and the Teaching Program and IVI Learning Center at IVI since 2004. Nico received the Spanish Fertility Society Award (2002, 2004), the Spanish Urology Association Award (2004), the American Society of Andrology Award (2007, 2010, 2011), and the Salud 2000 Foundation Award in 2010. Presently he is Coordinator ESHRE Andrology SIG.

 

 

 

Sarah Kimmins, PhD

Affiliation
McGill University
• Associate Professor - Reproductive Biology
• Canada Research Chair Tier II, Epigenetics, Reproduction and Development
• Centre for Research in Reproduction and Development (CRRD)

Clinical and research activity
Her research focuses on the molecular mechanisms of epigenetic inheritance. Particular interest is paternal health and how environmental exposures (diet, BMI, toxicants) alter fertility, clinical outcomes, the sperm epigenome, development and health of offspring. She is Chair of the Canadian Fertility and Andrology Society, Andrology Special Interest Group (2019-2021).

 

   

Csilla Krausz, MD, PhD

Affiliation
University of Florence
• Professor in Endocrinology and Research Group Leader
• Co-director of the Florence EAA Training Center in Andrology

Clinical and research activity
Csilla focuses on genetics and epigenetics of male infertility, hypogonadism, cryptorchidism, testis tumor and genomic instability of the male gamete. She is an Academician of the European Academy of Andrology (EAA) and she is currently the President of the EAA. Starting from 2017 she has been appointed as the Clinical lead of the European Society of Endocrinology (ESE) Reproductive Endocrinology Focus Area.

 

 

 

 

 

Moira O'Bryan, PhD.

Affiliation
Monash University in Melbourne Australia
• Professor and Head of the School of Biological Sciences.

Clinical and research activity
Her research encompasses: germ cell development and the relationship between sperm form and function, the genetic causes of human infertility, and the implications for ‘reproductive’ proteins on health broadly. She leads a multidisciplinary and highly collaborative research program spanning basic research and clinical medicine. She is a founding member of the International Male Infertility Genomics Consortium and is President of the Society for Reproductive Biology (Australia and New Zealand).

 

 

Allan Pacey, MBE, PhD, FRCOG

Affiliation

University of Sheffield
• Professor of Andrology
• Head of Department of Oncology and Metabolism

Clinical and research activity
Editor in Chief of Human Fertility; Member of Guideline Development Group, WHO Guidelines on Fertility care, Infertility and Subfertility; Chair of the UKNEQAS Andrology EQA Scheme Specialist Advisory Group; Trustee of the British Fertility Society Ltd; Trustee of the Progress Educational Trust. Research interests in sperm function, metabolism, nutrition, lifestyle and occupational influences on semen quality.

 

 

 

 

Satu Rautakallio-Hokkanen, BBA, Computer Science

Affiliation

• Chair, Fertility Europe
• Secretary, Finnish Infertility Association Simpukka

   

Frank Tüttelmann, MD

Affiliation
University of Münster, Germany
• Professor of Reproductive Genetics
• Deputy director Research and Teaching Institute of Human Genetics

Clinical and research activity
Frank is a specialist in human genetics with a focus on reproductive genetics and also a certified andrologist of the European Academy of Andrology. His primary research topic is male infertility and the majority of his publications deals with genetic causes of spermatogenic failure. He coordinates the German Research Foundation (DFG) funded Clinical Research Unit ‚Male Germ Cells: from Genes to Function‘ and is a founding member of the International Male Infertility Genomics Consortium.

 

 

 

 

Joris Veltman, PhD

Affiliation
Newcastle University
• Dean of the Biosciences Institute
• Jacobson Chair of Personalized Medicine at the Faculty of Medical Sciences.

Clinical and research activity
Joris studies genetic factors in male infertility and the impact of artificial reproductive technologies on the genome of the offspring. His research is funded by the Dutch Scientific Organisation, the Royal Society and the Wellcome Trust. He is a founding member of the International Male Infertility Genomics Consortium. In 2016, Profs. Veltman and Brunner were awarded the King Faisal International Prize for Medicine for pioneering the clinical application of next generation genetics.

Selected references:

Barratt CLR, Björndahl L, De Jonge CJ, Lamb DJ, Osorio Martini F, McLachlan R, Oates RD, van der Poel S, St John B, Sigman M, Sokol R and Tournaye, H (2017) The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities Hum Reprod Update 23, 660-680.
https://academic.oup.com/humupd/article/23/6/660/3979420

Barratt CLR, De Jonge CJ and Sharpe RM (2018) 'Man Up': the importance and strategy for placing male reproductive health centre stage in the political and research agenda Hum Reprod 33, 541-545.
https://academic.oup.com/humrep/article/33/4/541/4838372

De Jonge C, and Barratt C L R (2019) The present crisis in male reproductive health: an urgent need for a political, social, and research roadmap. Andrology 7, 762-68. https://onlinelibrary.wiley.com/doi/abs/10.1111/andr.12673

Barratt CL, Anderson RA, De Jonge C (2019). Male fertility: a window on the health of this generation and the next. Reprod Biomed Online. 39, 721-723.
https://www.rbmojournal.com/article/S1472-6483(19)30745-X/pdf

Leave no man behind. German Research Foundation (DFG) german research 1/2020