Recommended reading

Last updated: 22 October 2021

The use of expanded carrier screening of gamete donors
Molly R Payne, Anne-Bine Skytte, Joyce C Harper
Human Reproduction, Volume 36, Issue 6, June 2021, Pages 1702–1710,

Testicular function in males with infantile nephropathic cystinosis
J Rohayem, D Haffner, J F Cremers, S Huss, J Wistuba, D Weitzel, S Kliesch, K Hohenfellner on behalf of the interdisciplinary Cystinosis Group
Human Reproduction, Volume 36, Issue 5, May 2021, Pages 1191–1204,

Long-term follow-up of boys who have undergone a testicular biopsy for fertility preservation
M Kanbar, F de Michele, M G Giudice, L Desmet, J Poels, C Wyns
Human Reproduction, Volume 36, Issue 1, January 2021, Pages 26–39,

Semen quality in non-Hodgkin lymphoma survivors: a monocentric retrospective study
Francesco Pallotti, Marianna Pelloni, Fabiana Faja, Silvia Di Chiano, Alice Di Rocco, Andrea Lenzi, Francesco Lombardo, Donatella Paoli
Human Reproduction, Volume 36, Issue 1, January 2021, Pages 16–25,

The impact of male factor infertility on early and late morphokinetic parameters: a retrospective analysis of 4126 time-lapse monitored embryos
C R Sacha, I Dimitriadis, G Christou, K James, M L Brock, S T Rice, P Bhowmick, C L Bormann, I Souter
Author Notes
Human Reproduction, Volume 35, Issue 1, January 2020, Pages 24–31,

An age-based sperm nomogram: the McGill reference guide
Mali Salmon-Divon, Guy Shrem, Jacques Balayla, Tamar Nehushtan, Alexander Volodarsky-Perel, Naama Steiner, Weon-Young Son, Michael H Dahan
Author Notes
Human Reproduction, Volume 35, Issue 10, October 2020, Pages 2213–2225,

DNA fragmentation of sperm: a radical examination of the contribution of oxidative stress and age in 16 945 semen samples
D A Vaughan, E Tirado, D Garcia, V Datta, D Sakkas
Author Notes
Human Reproduction, Volume 35, Issue 10, October 2020, Pages 2188–2196,

IUI: review and systematic assessment of the evidence that supports global recommendations.
Cohlen B, Bijkerk A, Van der Poel S, Ombelet W.
Hum Reprod Update. 2018 May 1;24(3):300-319. doi: 10.1093/humupd/dmx041.
PMID: 29452361 Review.

The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo.
Castillo J, Jodar M, Oliva R.
Hum Reprod Update. 2018 Sep 1;24(5):535-555. doi: 10.1093/humupd/dmy017.
PMID: 29800303 Review.

Temporal trends in sperm count: a systematic review and meta-regression analysis.
Levine H, Jørgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Mindlis I, Pinotti R, Swan SH.
Hum Reprod Update. 2017 Nov 1;23(6):646-659. doi: 10.1093/humupd/dmx022.
PMID: 28981654 Free PMC article. Review.

Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies.
Salas-Huetos A, Bulló M, Salas-Salvadó J.
Hum Reprod Update. 2017 Jul 1;23(4):371-389. doi: 10.1093/humupd/dmx006.
PMID: 28333357 Review.

Sperm recovery and ICSI outcomes in Klinefelter syndrome: a systematic review and meta-analysis.
Corona G, Pizzocaro A, Lanfranco F, Garolla A, Pelliccione F, Vignozzi L, Ferlin A, Foresta C, Jannini EA, Maggi M, Lenzi A, Pasquali D, Francavilla S; Klinefelter ItaliaN Group (KING).
Hum Reprod Update. 2017 May 1;23(3):265-275. doi: 10.1093/humupd/dmx008.
PMID: 28379559 Review.

Role of genetics and epigenetics in male infertility Sezgin Gunes,Sandro C. Esteves, Andrologia Volume 53, Issue 1 e13586
Clinical Reproductive Science Michael Carroll (Editor) Wiley-Blackwell ISBN: 978-1-118-97595-4

Special applications of intracytoplasmic sperm injection: the influence of sperm count, motility, morphology, source and sperm antibody on the outcome of ICSI Zsolt P. Nagy, Greta Verheyen, Herman Tournaye, André C. Van Steirteghem Human Reproduction, Volume 13, Issue, Pages 143–154,

Improved sperm kinematics in semen samples collected after 2 h versus 4–7 days of ejaculation abstinence H. Alipour, G. Van Der Horst, O.B. Christiansen, F. Dardmeh, N. Jørgensen ... Human Reproduction, Volume 32, Issue 7, July 2017, Pages 1364–1372,

DNA fragmentation of sperm: a radical examination of the contribution of oxidative stress and age in 16 945 semen samples D A Vaughan, E Tirado, D Garcia, V Datta, D Sakkas Human Reproduction, Volume 35, Issue 10, October 2020, Pages 2188–2196,

Prediction model for clinical pregnancy for ICSI after surgical sperm retrieval in different types of azoospermia Jingyu Song, Longjie Gu, Xinling Ren, Yang Liu, Kun Qian ... Human Reproduction, Volume 35, Issue 9, September 2020, Pages 1972–1982,

Laurentino S, Cremers JF, Horsthemke B, Tüttelmann F, Czeloth K, Zitzmann M, Pohl E, Rahmann S, Schröder C, Berres S, Redmann K, Krallmann C, Schlatt S, Kliesch S, Gromoll J. A germ cell-specific ageing pattern in otherwise healthy men. Aging Cell. 2020 Oct;19(10):e13242. doi: 10.1111/acel.13242. Epub 2020 Sep 20. PMID: 32951333; PMCID: PMC7576283.

Åsenius F, Danson AF, Marzi SJ. DNA methylation in human sperm: a systematic review. Hum Reprod Update. 2020 Nov 1;26(6):841-873. doi: 10.1093/humupd/dmaa025. PMID: 32790874.

Leitão E, Di Persio S, Laurentino S, Wöste M, Dugas M, Kliesch S, Neuhaus N, Horsthemke B. The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis. Clin Epigenetics. 2020 May 6;12(1):61. doi: 10.1186/s13148-020-00854-0. PMID: 32375885; PMCID: PMC7204326.

Laurentino S, Heckmann L, Di Persio S, Li X, Meyer Zu Hörste G, Wistuba J, Cremers JF, Gromoll J, Kliesch S, Schlatt S, Neuhaus N. High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting. Clin Epigenetics. 2019 Aug 28;11(1):127. doi: 10.1186/s13148-019-0720-3. PMID: 31462300; PMCID: PMC6714305.

Goossens E, Jahnukainen K, Mitchell RT, van Pelt A, Pennings G, Rives N, Poels J, Wyns C, Lane S, Rodriguez-Wallberg KA, Rives A, Valli-Pulaski H, Steimer S, Kliesch S, Braye A, Andres MM, Medrano J, Ramos L, Kristensen SG, Andersen CY, Bjarnason R, Orwig KE, Neuhaus N, Stukenborg JB. Fertility preservation in boys: recent developments and new insights †. Hum Reprod Open. 2020 Jun 6;2020(3):hoaa016. doi: 10.1093/hropen/hoaa016. PMID: 32529047; PMCID: PMC7275639. 

Sharma S, Wistuba J, Pock T, Schlatt S, Neuhaus N. Spermatogonial stem cells: updates from specification to clinical relevance. Hum Reprod Update. 2019 May 1;25(3):275-297. doi: 10.1093/humupd/dmz006. PMID: 30810745

For varicocele
Samplaski MK, Lo KC, Grober ED, Zini A, Jarvi KA. Varicocelectomy to “upgrade” semen quality to allow couples to use less invasive forms of assisted reproductive technology. Fertility and Sterility. oct 2017;108(4):609 12.

Johnson D, Sandlow J. Treatment of varicoceles: techniques and outcomes. Fertil Steril. 2017 Sep;108(3):378-384.

Silay MS, Hoen L, Quadackaers J, Undre S, Bogaert G, Dogan HS, Kocvara R, Nijman RJM, Radmayr C, Tekgul S, Stein R. Treatment of Varicocele in Children and Adolescents: A Systematic Review and Meta-analysis from the European Association of Urology/European Society for Paediatric Urology Guidelines Panel. Eur Urol. 2019 Mar;75(3):448-461.

Paternal age
Horta F, Vollenhoven B, Healey M, Busija L, Catt S, Temple-Smith P. Male ageing is negatively associated with the chance of live birth in IVF/ICSI cycles for idiopathic infertility. Hum Reprod. 2019 Dec 1;34(12):2523-2532.

Oldereid NB, Wennerholm UB, Pinborg A, Loft A, Laivuori H, Petzold M, Romundstad LB, Söderström-Anttila V, Bergh C. The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis. Hum Reprod Update. 2018 May 1;24(3):320-389.

Maher GJ, Rajpert-De Meyts E, Goriely A, Wilkie AO. Cellular correlates of selfish spermatogonial selection. Andrology. 2016 May;4(3):550-3. doi: 10.1111/andr.12185. Epub 2016 Apr 26. PMID: 27115825; PMCID: PMC4879506.

and as an alternative interpretation of the theory the following:
Pohl E, Höffken V, Schlatt S, Kliesch S, Gromoll J, Wistuba J. Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells. Andrology. 2019 Nov;7(6):827-839. doi: 10.1111/andr.12665. Epub 2019 Jun 27. PMID: 31250567.

Pohl E, Gromoll J, Kliesch S, Wistuba J. An alternative interpretation of cellular 'selfish spermatogonial selection'-clusters in the human testis indicates the need for 3-D-analyses. Andrology. 2016 Mar;4(2):213-7. doi: 10.1111/andr.12142. Epub 2016 Feb 19. PMID: 26891892.

Maher GJ, Ralph HK, Ding Z, Koelling N, Mlcochova H, Giannoulatou E, Dhami P, Paul DS, Stricker SH, Beck S, McVean G, Wilkie AOM, Goriely A. Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes. Genome Res. 2018 Dec;28(12):1779-1790